Microglia take control in chronic pain
نویسندگان
چکیده
منابع مشابه
Microglia disrupt mesolimbic reward circuitry in chronic pain.
Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease in opioid-evoked DA release in the ventral striatum, suggesting that the occurrence of chronic pain impairs reward-related behaviors. However, mechanisms by which pain modifies DA transmission remain elusive. Using in vivo microdialysis and microinjection of drugs into the mesolimbic DA system, we demonstrat...
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BACKGROUND Back pain syndrome is a common problem, not only orthopedic, but also psychological, social and economic. In research and clinical practice, the tendency to differentiate between physiological aspects of pain and the psychological, social and economic factors related to pain is dominant. The goal of this paper is to evaluate pain control perception in patients with chronic back pain ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2013
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3442